The mediating effects of sleep quality in the relationship between loneliness and depression among middle-aged and older adults

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The mediating effects of sleep quality in the relationship between loneliness and depression among middle-aged and older adults
  • Collaborators., G. D. a. I. Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet 403, 2133–2161. (2024).

  • Malhi, G. S. & Mann, J. J. Depression. Lancet 392, 2299–2312. (2018).

    Article 
    PubMed 

    Google Scholar 

  • da Silva, J., Gonçalves-Pereira, M., Xavier, M. & Mukaetova-Ladinska, E. B. Affective disorders and risk of developing dementia: systematic review. Br. J. Psychiatry 202, 177–186. (2013).

    Article 
    PubMed 

    Google Scholar 

  • Rodda, J., Walker, Z. & Carter, J. Depression in older adults. BMJ (Clin. Res. Ed.) 343, d5219. (2011).

    Article 

    Google Scholar 

  • Cai, H. et al. Global prevalence of depression in older adults: a systematic review and meta-analysis of epidemiological surveys. Asian J. Psychiatr. 80, 103417. (2023).

    Article 
    PubMed 
    MATH 

    Google Scholar 

  • Tang, T., Jiang, J. & Tang, X. Prevalence of depressive symptoms among older adults in mainland China: a systematic review and meta-analysis. J. Affect. Disord. 293, 379–390. (2021).

    Article 
    PubMed 
    MATH 

    Google Scholar 

  • Bergman, Y. S. & Segel-Karpas, D. Aging anxiety, loneliness, and depressive symptoms among middle-aged adults: the moderating role of ageism. J. Affect. Disord. 290, 89–92. (2021).

    Article 
    PubMed 

    Google Scholar 

  • McKenna-Plumley, P. E., Turner, R. N., Yang, K. & Groarke, J. M. Experiences of loneliness across the lifespan: a systematic review and thematic synthesis of qualitative studies. Int. J. Qual. Stud. Health Well Being 18, 2223868. (2023).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Jylhä, M. Old age and loneliness: cross-sectional and longitudinal analyses in the Tampere Longitudinal Study on Aging. Can. J. Aging 23, 157–168. (2004).

    Article 
    PubMed 
    MATH 

    Google Scholar 

  • Aartsen, M. & Jylhä, M. Onset of loneliness in older adults: results of a 28 year prospective study. Eur. J. Ageing 8, 31–38. (2011).

    Article 
    PubMed 
    PubMed Central 
    MATH 

    Google Scholar 

  • Valtorta, N. & Hanratty, B. Loneliness, isolation and the health of older adults: do we need a new research agenda?. J. R. Soc. Med. 105, 518–522. (2012).

    Article 
    PubMed 
    PubMed Central 
    MATH 

    Google Scholar 

  • Quadt, L., Esposito, G., Critchley, H. D. & Garfinkel, S. N. Brain-body interactions underlying the association of loneliness with mental and physical health. Neurosci. Biobehav. Rev. 116, 283–300. (2020).

    Article 
    PubMed 
    MATH 

    Google Scholar 

  • Manoli, A., McCarthy, J. & Ramsey, R. Estimating the prevalence of social and emotional loneliness across the adult lifespan. Sci. Rep. 12, 21045. (2022).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Van As, B. A. L., Imbimbo, E., Franceschi, A., Menesini, E. & Nocentini, A. The longitudinal association between loneliness and depressive symptoms in the elderly: a systematic review. Int. Psychogeriatr. 34, 657–669. (2022).

    Article 
    PubMed 

    Google Scholar 

  • Furutani, M., Guo, T., Hall, K. & Zhou, X. Relationship between mental health and the quality of sleep during the first self-restraint in Japanese workers: a cross-sectional survey. Health Psychol. Behav. Med. 10, 748–761. (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Hawkley, L. C. & Cacioppo, J. T. Loneliness matters: a theoretical and empirical review of consequences and mechanisms. Ann. Behav. Med. 40, 218–227. (2010).

    Article 
    PubMed 
    MATH 

    Google Scholar 

  • Wong, N. M. et al. Loneliness in late-life depression: structural and functional connectivity during affective processing. Psychol. Med. 46, 2485–2499. (2016).

    Article 
    CAS 
    PubMed 
    MATH 

    Google Scholar 

  • Ypsilanti, A., Lazuras, L., Powell, P. & Overton, P. Self-disgust as a potential mechanism explaining the association between loneliness and depression. J. Affect. Disord. 243, 108–115. (2019).

    Article 
    PubMed 

    Google Scholar 

  • Charest, J. & Grandner, M. A. Sleep and athletic performance: impacts on physical performance, mental performance, injury risk and recovery, and mental health. Sleep Med. Clin. 15, 41–57. (2020).

    Article 
    PubMed 
    PubMed Central 
    MATH 

    Google Scholar 

  • Ekström, H., Svensson, M., Elmståhl, S. & Wranker, L. S. The association between loneliness, social isolation, and sleep disturbances in older adults: a follow-up study from the Swedish good aging in Skåne project. SAGE Open Med. 12, 20503121231222824. (2024).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Livingston, G., Blizard, B. & Mann, A. Does sleep disturbance predict depression in elderly people? A study in inner London. Br. J. Gener. Pract. 43, 445–448 (1993).

    CAS 

    Google Scholar 

  • Fang, H., Tu, S., Sheng, J. & Shao, A. Depression in sleep disturbance: a review on a bidirectional relationship, mechanisms and treatment. J. Cell. Mol. Med. 23, 2324–2332. (2019).

    Article 
    PubMed 
    PubMed Central 
    MATH 

    Google Scholar 

  • Mirchandaney, R., Asarnow, L. D. & Kaplan, K. A. Recent advances in sleep and depression. Curr. Opin. Psychiatry 36, 34–40. (2023).

    Article 
    PubMed 

    Google Scholar 

  • Liu, Y. et al. The mediating role of sleep quality on the relationship between perceived stress and depression among the elderly in urban communities: a cross-sectional study. Public Health 149, 21–27. (2017).

    Article 
    CAS 
    PubMed 
    MATH 

    Google Scholar 

  • Wang, Q., Zan, C., Jiang, F., Shimpuku, Y. & Chen, S. Association between loneliness and its components and cognitive function among older Chinese adults living in nursing homes: a mediation of depressive symptoms, anxiety symptoms, and sleep disturbances. BMC Geriatr. 22, 959. (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Lu, Y. et al. Loneliness, depression and sleep quality among the type 2 diabetic patients during COVID-19 local epidemic: a mediation analysis. Nurs Open 10, 6345–6356. (2023).

    Article 
    PubMed 
    PubMed Central 
    MATH 

    Google Scholar 

  • Gu, S. et al. Effects of Coronavirus-19 induced loneliness on mental health: sleep quality and intolerance for uncertainty as mediators. Front. Psychiatry 12, 738003. (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Andresen, E. M., Malmgren, J. A., Carter, W. B. & Patrick, D. L. Screening for depression in well older adults: evaluation of a short form of the CES-D (Center for Epidemiologic Studies Depression Scale). Am. J. Prevent. Med. 10, 77–84 (1994).

    Article 
    CAS 
    MATH 

    Google Scholar 

  • Peng, S., Wang, S. & Feng, X. L. Multimorbidity, depressive symptoms and disability in activities of daily living amongst middle-aged and older Chinese: evidence from the China Health and Retirement Longitudinal Study. J. Affect. Disord. 295, 703–710. (2021).

    Article 
    PubMed 
    MATH 

    Google Scholar 

  • Hays, R. D. & DiMatteo, M. R. A short-form measure of loneliness. J. Personal. Assess. 51, 69–81. (1987).

    Article 
    CAS 
    MATH 

    Google Scholar 

  • Wegner, L. & Liu, S. Positive and negative experiences with the COVID-19 pandemic among lonely and non-lonely populations in Germany. Front. Public Health 10, 1067038. (2023).

    Article 
    PubMed 
    PubMed Central 
    MATH 

    Google Scholar 

  • Buysse, D. J., Reynolds, C. F. 3rd., Monk, T. H., Berman, S. R. & Kupfer, D. J. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 28, 193–213. (1989).

    Article 
    CAS 
    PubMed 
    MATH 

    Google Scholar 

  • Zhang, C. et al. Reliability, validity, and factor structure of pittsburgh sleep quality index in community-based centenarians. Front. Psychiatry 11, 573530. (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Hayes, A. F. & Rockwood, N. J. Regression-based statistical mediation and moderation analysis in clinical research: observations, recommendations, and implementation. Behav. Res. Therapy 98, 39–57. (2017).

    Article 
    MATH 

    Google Scholar 

  • Wu, N. W. et al. Analysis of the status of depression and the influencing factors in middle-aged and older adults in China. J. Sichuan Univ. Med. Sci. Ed. 52, 767–771. (2021).

    Article 
    MATH 

    Google Scholar 

  • Wang, D. et al. Depression status and its influencing factors among the elderly aged 60 years and above in three provinces of China. Zhonghua liu xing bing xue za zhi 43, 1925–1931. (2022).

    Article 
    CAS 
    PubMed 
    MATH 

    Google Scholar 

  • Henking, C., Reeves, A. & Chrisinger, B. Global inequalities in mental health problems: understanding the predictors of lifetime prevalence, treatment utilisation and perceived helpfulness across 111 countries. Prevent. Med. 177, 107769. (2023).

    Article 

    Google Scholar 

  • Zhao, Y. et al. Late-life depression: epidemiology, phenotype, pathogenesis and treatment before and during the COVID-19 pandemic. Front. Psychiatry 14, 1017203. (2023).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kundakovic, M. & Rocks, D. Sex hormone fluctuation and increased female risk for depression and a nxiety disorders: from clinical evidence to molecular mechanisms. Front. Neuroendocrinol. 66, 101010. (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 
    MATH 

    Google Scholar 

  • Nakagomi, A., Shiba, K., Hanazato, M., Kondo, K. & Kawachi, I. Does community-level social capital mitigate the impact of widowhood & living alone on depressive symptoms?: a prospective, multi-level study. Soc. Sci. Med. 259, 113140. (2020).

    Article 
    PubMed 

    Google Scholar 

  • Widhowati, S. S., Chen, C. M., Chang, L. H., Lee, C. K. & Fetzer, S. Living alone, loneliness, and depressive symptoms among Indonesian older women. Health Care Women Int. 41, 984–996. (2020).

    Article 
    PubMed 

    Google Scholar 

  • Srivastava, S., Debnath, P., Shri, N. & Muhammad, T. The association of widowhood and living alone with depression among older adults in India. Sci. Rep. 11, 21641. (2021).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Freak-Poli, R., Kung, C. S. J., Ryan, J. & Shields, M. A. Social isolation, social support, and loneliness profiles before and after spousal death and the buffering role of financial resources. J. Gerontol. Ser. B Psychol. Sci. Soc. Sci. 77, 956–971. (2022).

    Article 

    Google Scholar 

  • Lorant, V. et al. Depression and socio-economic risk factors: 7-year longitudinal popula tion study. Br. J. Psychiatry 190, 293–298. (2007).

    Article 
    PubMed 
    MATH 

    Google Scholar 

  • Jiang, C. H., Zhu, F. & Qin, T. T. Relationships between chronic diseases and depression among middle-aged and elderly people in China: a prospective study from CHARLS. Curr. Med. Sci. 40, 858–870. (2020).

    Article 
    PubMed 
    MATH 

    Google Scholar 

  • Jung, S. J. et al. Association between body size, weight change and depression: systematic review and meta-analysis. Br. J. Psychiatry 211, 14–21. (2017).

    Article 
    PubMed 
    MATH 

    Google Scholar 

  • Herhaus, B., Kersting, A., Brähler, E. & Petrowski, K. Depression, anxiety and health status across different BMI classes: a representative study in Germany. J. Affect. Disord. 276, 45–52. (2020).

    Article 
    PubMed 

    Google Scholar 

  • Roberts, R. E. & Duong, H. T. Obese youths are not more likely to become depressed, but depressed youths are more likely to become obese. Psychol. Med. 43, 2143–2151. (2013).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • He, K., Pang, T. & Huang, H. The relationship between depressive symptoms and BMI: 2005–2018 NHANES data. J. Affect. Disord. 313, 151–157. (2022).

    Article 
    PubMed 
    MATH 

    Google Scholar 

  • Griffin, S. C., Williams, A. B., Ravyts, S. G., Mladen, S. N. & Rybarczyk, B. D. Loneliness and sleep: a systematic review and meta-analysis. Health Psychol. Open 7, 2055102920913235. (2020).

    Article 
    PubMed 
    PubMed Central 
    MATH 

    Google Scholar 

  • Åkerstedt, T. et al. Predicting sleep quality from stress and prior sleep–a study of day-to-day covariation across six weeks. Sleep Med. 13, 674–679. (2012).

    Article 
    PubMed 
    MATH 

    Google Scholar 

  • Campagne, D. M. Stress and perceived social isolation (loneliness). Arch. Gerontol. Geriatr. 82, 192–199. (2019).

    Article 
    PubMed 

    Google Scholar 

  • McHugh, J. E. & Lawlor, B. A. Perceived stress mediates the relationship between emotional loneliness and sleep quality over time in older adults. Br. J. Health Psychol. 18, 546–555. (2013).

    Article 
    PubMed 

    Google Scholar 

  • Yap, Y., Slavish, D. C., Taylor, D. J., Bei, B. & Wiley, J. F. Bi-directional relations between stress and self-reported and actigraphy-assessed sleep: a daily intensive longitudinal study. Sleep 43, 3. (2020).

    Article 
    PubMed 

    Google Scholar 

  • Lam, J. A. et al. Neurobiology of loneliness: a systematic review. Neuropsychopharmacology 46, 1873–1887. (2021).

    Article 
    PubMed 
    PubMed Central 
    MATH 

    Google Scholar 

  • Joo, H. J., Kwon, K. A., Shin, J., Park, S. & Jang, S. I. Association between sleep quality and depressive symptoms. J. Affect. Disord. 310, 258–265. (2022).

    Article 
    PubMed 
    MATH 

    Google Scholar 

  • Irwin, M. R., Carrillo, C. & Olmstead, R. Sleep loss activates cellular markers of inflammation: sex differences. Brain Behav. Immunity 24, 54–57. (2010).

    Article 
    CAS 
    MATH 

    Google Scholar 

  • Irwin, M. R., Olmstead, R. & Carroll, J. E. Sleep disturbance, sleep duration, and inflammation: a systematic review and meta-analysis of cohort studies and experimental sleep deprivation. Biol. Psychiatry 80, 40–52. (2016).

    Article 
    PubMed 
    MATH 

    Google Scholar 

  • Mac-Giollabhui, N., Ng, T. H., Ellman, L. M. & Alloy, L. B. The longitudinal associations of inflammatory biomarkers and depression revisited: systematic review, meta-analysis, and meta-regression. Mol. Psychiatry 26, 3302–3314. (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Madrid-Valero, J. J. & Gregory, A. M. Behaviour genetics and sleep: a narrative review of the last decade of quantitative and molecular genetic research in humans. Sleep Med. Rev. 69, 101769. (2023).

    Article 
    CAS 
    PubMed 
    MATH 

    Google Scholar 

  • Charrier, A., Olliac, B., Roubertoux, P. & Tordjman, S. Clock genes and altered sleep-wake rhythms: their role in the development of psychiatric disorders. Int. J. Mol. Sci. 18, 938. (2017).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Hammen, C. Stress and depression. Annu. Rev. Clin. Psychol. 1, 293–319. (2005).

    Article 
    PubMed 
    MATH 

    Google Scholar 

  • Xia, N. & Li, H. Loneliness, social isolation, and cardiovascular health. Antioxid. Redox Signal. 28, 837–851. (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 
    MATH 

    Google Scholar 

  • Cacioppo, J. T. et al. Loneliness across phylogeny and a call for comparative studies and animal models. Perspect. Psychol. Sci. 10, 202–212. (2015).

    Article 
    PubMed 
    PubMed Central 
    MATH 

    Google Scholar 

  • Yang, L. et al. The effects of psychological stress on depression. Curr. Neuropharmacol. 13, 494–504. (2015).

    Article 
    CAS 
    PubMed 
    PubMed Central 
    MATH 

    Google Scholar 

  • da Estrela, C., McGrath, J., Booij, L. & Gouin, J. P. Heart rate variability, sleep quality, and depression in the context of chronic stress. Ann. Behav. Med. 55, 155–164. (2021).

    Article 
    PubMed 
    MATH 

    Google Scholar 

  • Lo-Martire, V., Berteotti, C., Zoccoli, G. & Bastianini, S. Improving sleep to improve stress resilience. Curr. Sleep Med. Rep. 10, 23–33. (2024).

    Article 

    Google Scholar 

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